منابع مشابه
The effects of Amped Up on hemodynamic function and energy expenditure at rest
Methods Eight male (23.0 ± 3.70 years, 210.69 ± 36.17 lbs, 71.81 ± 3.10 in) and ten female (23.6 ± 4.81 years, 147.95 ± 12.63 lbs, 67.88 ± 4.06 in) apparently healthy, physically active individuals participated in this study. Participants reported to the lab on a 10-hour fast and performed baseline testing on resting energy expenditure (REE), heart rate, and blood pressure. Subjects were then r...
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Despite recent advances in the treatment for metastatic prostatic adenocarcinoma, clinical management of this tumor type remains a major challenge, and there is as of yet no durable cure for advanced disease. Developing pathways that could be co-targeted alongside the androgen receptor or that would otherwise thwart the development of the CRPC is a current translational and clinical priority. I...
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Antimicrobial peptides (AMPs) are widely expressed and rapidly induced at epithelial surfaces to repel assault from diverse infectious agents including bacteria, viruses, fungi and parasites. Much information suggests that AMPs act by mechanisms that extend beyond their capacity to serve as gene-encoded antibiotics. For example, some AMPs alter the properties of the mammalian membrane or intera...
متن کاملPerampanel: Getting AMPed for AMPA Targets.
Commentary In the April 18 issue of the journal Neurology, Dr. Krauss and an international group of investigators presented the results of a multicenter, double-blind, placebo-controlled, randomized dose response trial of perampanel used as adjunct to other antiepileptic drugs (AEDs) in patients with refractory partial-onset seizures (1). Perampanel, a new AED currently undergoing investigation...
متن کاملAMPED: a new platform for picolinate based luminescent lanthanide chelates.
The synthesis of a new nonacoordinating ligand based on an AMPED (6-amino-6-methylperhydro-1,4-diazepine) scaffold functionalized by three picolinate (6-carboxy-2-methylpyridine) arms is described. Coordination of lanthanide cations (Ln = Eu and Tb) was investigated by spectrophotometric titrations monitored by UV-Vis absorption and steady-state emission spectroscopy, showing the formation of [...
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ژورنال
عنوان ژورنال: Nature Nanotechnology
سال: 2016
ISSN: 1748-3387,1748-3395
DOI: 10.1038/nnano.2016.76